Two large trials, DREAM and MENSA have found IL-5 therapy with mepolizumab to lower risk of exacerbation in patients with asthma with an eosinophilic phenotype.
Allergic rhinitis affects 1 in 5 people in the US and is associated with high economic burden. Allergic rhinitis (AR) can lead to decreased energy, poor concentration, disturbed sleep, and decrements in performance at school and work.
In 2011, US costs of AR were $14 billion, with 60% towards prescription medications. Additional dollars were spent to treat conditions for which AR is a predisposing factor such as asthma, sinusitis.
Subcutaneous immunotherapy just commemorated its centennial anniversary. It is indicated to treat AR in patients with symptoms not adequately controlled by medications, avoidance measures, or those experiencing adverse effects of medications, or who wish to reduce long term use of medication.
Patients with newly diagnosed AR initiating immunotherapy incur significantly lower health care costs than matched control subjects beginning 3 months after immunotherapy initiations and continuing throughout the 18-month follow-up period.
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Two large trials, DREAM and MENSA have found IL-5 therapy with mepolizumab to lower risk of exacerbation in patients with asthma with an eosinophilic phenotype.
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Recent studies have suggested that early regular exposure to allergenic foods may reduce the risk of food allergy.