Epinephrine is the first-line therapy for anaphylactic reactions. The market now includes Auvi-Q, a self-injectable epinephrine with a prompting audiovisual system. There is a comparative study of the traditional EpiPen vs Auvi-Q that indicates that the 0.3mg dose of epinephrine was bioequivalent with similar peak and epinephrine exposure. Safety and tolerability were also similar. Although, Auvi-Q had less injection site pain and bleeding. The self-instructing delivery system may also ease the anxiety of users unfamiliar with injections during an emergency.
Edwards ES, Gunn R, Simons ER, et al : Bioavailability of epinephrine from Auvi-Q compared with EpiPen. Ann All Asthma Immunol. 2013; 11:132-137.
You Might Also Enjoy...
Two large trials, DREAM and MENSA have found IL-5 therapy with mepolizumab to lower risk of exacerbation in patients with asthma with an eosinophilic phenotype.
Mold allergy is difficult to diagnose due to lack of standardized test material.
The current standard for diagnosis of Eosinophilic Esophagitis (EoE) is endoscopy with esophageal biopsy to determine the eosinophil count
Skin prick testing and serum IgE measurement are limited in their ability to predict positive or negative responses to oral peanut challenge.
Bronchial Thermoplasty (BT) has been shown to result in significant improvements in a number of asthma control measures in three randomized clinical trials in patients with moderate-to-severe, persistent asthma.
Recent studies have suggested that early regular exposure to allergenic foods may reduce the risk of food allergy.
