Two large trials, DREAM and MENSA have found IL-5 therapy with mepolizumab to lower risk of exacerbation in patients with asthma with an eosinophilic phenotype.
Recent studies have suggested that early regular exposure to allergenic foods may reduce the risk of food allergy. Ingestion of egg was tested in a randomized double-blind trial that included 86 infants with a history of eczema.
Infants were assigned to receive a once-daily, 1-teaspoon dose of pasteurized raw whole egg powder or rice powder. At 8 months, both groups had an observed feeding followed by introduction of cooked egg.
A high number of infants had significant reactions to the initial ingestion with egg, although at 12 months fewer children receiving regular egg feedings were allergic to egg compared to controls receiving rice feedings. Unfortunately, the study was stopped prior to enrolling sufficient numbers to show statistical significance.
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Two large trials, DREAM and MENSA have found IL-5 therapy with mepolizumab to lower risk of exacerbation in patients with asthma with an eosinophilic phenotype.
Mold allergy is difficult to diagnose due to lack of standardized test material.
The current standard for diagnosis of Eosinophilic Esophagitis (EoE) is endoscopy with esophageal biopsy to determine the eosinophil count
Skin prick testing and serum IgE measurement are limited in their ability to predict positive or negative responses to oral peanut challenge.
Bronchial Thermoplasty (BT) has been shown to result in significant improvements in a number of asthma control measures in three randomized clinical trials in patients with moderate-to-severe, persistent asthma.
We are closer to having the first FDA approved therapy for peanut allergy; this is truly a groundbreaking development. Patients are exposed to controlled doses of peanut protein, with the dose increased over time. Ideally this will induce a tolerance.